James L. Cornette, Emeritus Professor of Mathematics, University Professor
Iowa State University. Ames, IA 50011
E-mail: cornette@iastate.edu

Sequential and structural analysis of immune system proteins.

A collaboration begun in 1985 at the National Cancer Institute with

• Charles DeLisi now Dean of Engineering at Boston University
• Jay A. Berzofsky now Chief, Molecular Immunogenetics and Vaccine Research Section at the National Cancer Institute, and
• Hannah Margalit, now Professor of Microbiology, Hadassah Medical School, Hebrew University, Jerusalem

produced 21 journal articles, 10 review and expository articles, and three patents, including

• Chao Zhang, James L. Cornette, and Charles DeLisi, Consistency in the structural energetics of protein folding and peptide recognition, Protein Sci. 6 (1997) 1057-1064.
• Chao Zhang, James Cornette, Jay Berzofsky, and Charles DeLisi, The organization of human Leucocyte antigen class I epitopes in HIV genome products: implications for vaccine design, Vaccine (1997) 15 (1997) 1291-1302.
• Chao Zhang, George Vasmatzis, James Cornette, and Charles DeLisi, Determination of Atomic Desolvation Energies from the Structures of Crystallized Proteins, J. Mol. Biol. (1997) 267, 707-726.
• George Vasmatzis, Chao Zhang, James L. Cornette, and Charles DeLisi, Computational determination of side chain specificity for pockets in class I MHC molecules, Mol. Immunol. (1997) 16, 1231-1239.
• George Vasmatzis, James Cornette, Ugur Sezerman, and Charles DeLisi, TcR recognition of the MHC-peptide dimer: structural properties of a ternary complex, J. Mol. Biol. (1996) 261 72-89.
• Cornette, J L, Margalit, H, Berzofsky, J A, and DeLisi, C, Periodic variation in side-chain polarities of T-cell antigenic peptides correlates with their structure and activity. Proc. Natl. Acad. Sci USA 92 (1995), 8368-8372.
• Richard D. England, Marika C. Kullberg, James L. Cornette, and Jay A. Berzofsky, Molecular analysis of a heteroclitic T-cell response to the immunodominant epitope of sperm whale myoglobin: Implications for peptide partial agonists. J. of Immunology 55 (1995), 4295-4306.
• Anne S. De Groot, Gabriel E. Meister, James L. Cornette, Hanah Margalit, Charles DeLisi, and Jay A. Berzofsky, Computer prediction of T cell epitopes, New Generation Vaccines, Myron Levin, Graeme Woodrow, James B. Caper, and Gary S. Cobon, eds., Marcell Dekker, NY, 1997.
• J. L. Cornette, B. L. King, M. D. Silverman, and C. DeLisi, Graphical representations of the class I MHC cleft, J. Mol. Graphics 11 (1993), 174-179 and 187.
• J. L. Cornette, H. Margalit, C. DeLisi, and J. A. Berzofsky, The amphipathic helix as a structural feature in T-cell recognition, Richard M. Epand, (ed.), The Amphipathic Helix, CRC Press, Boca Raton, Florida, 333-346 (1993).

Patents

• Patent No. 5,081,226 issued January 14, 1992
  Jay A. Berzofsky, Cecelia S. Ouyang, Charles DeLisi, Hanah Margalit, J. L. Cornette, and K. Cease: Synthetic peptides which induce cellular immunity to the AIDS virus and viral proteins.
• Patent No. 5,495,423 issued February 27, 1996.
  Charles DeLisi, James L. Cornette, Ugur Sezerman, Rakefet Rosenfeld, Sandor Vajda: A general strategy for vaccine and drug design.
• Patent No 5,593,973 issued December 10, 1996.
  Charles DeLisi, James L. Cornette, Benjamin A. King, and Michael Silverman: Molecular modeling method and system.